![]() Methamphetamine use can also cause strokes and death. This violent, aggressive behavior is usually coupled with extreme paranoia. Long-term use, high dosages, or both can bring on full-blown toxic psychosis (often exhibited as violent, aggressive behavior). Users can obsessively scratch their skin to get rid of these imagined insects. It is an important clinical sign in physical diagnosis, especially in emergency department or intensive care unit patients, where it can signal a stroke, impending brain herniation. Chronic use can cause paranoia, hallucinations, repetitive behavior (such as compulsively cleaning, grooming or disassembling and assembling objects), and delusions of parasites or insects crawling under the skin. Blown pupil is an informal medical term used by physicians and nurses to refer to sudden pupillary dilation and loss of ability to constrict in response to light. In some cases, users forego food and sleep and take more meth every few hours for days, 'binging' until they run out of the drug or become too disorganized to continue. Long-term, Methamphetamine is addictive, and users can develop a tolerance quickly, needing larger amounts to get high. The physical effects include dilated pupils, higher body temperature. Other possible immediate effects include increased wakefulness and insomnia, decreased appetite, irritability/ aggression, anxiety, nervousness, convulsions and heart attack. Typically an LSD user feels the effects of the drug 30 to 90 minutes after taking it. After the initial "rush," there is typically a state of high agitation that in some individuals can lead to violent behavior. Snorting or swallowing meth produces euphoria - a high, but not a rush. Immediately after smoking or injection, the user experiences an intense sensation, called a "rush" or "flash," that lasts only a few minutes and is described as extremely pleasurable. ![]() Dilated pupils occur when pupils increase in size. It can signal a stroke, impending brain herniation or other brain catastrophes in patients of intensive care unit. Prolonged cocaine snorting can result in ulceration of the mucous membrane of the nose. The blown pupil is an informal medical term used by physicians to refer to sudden papillary dilation and loss of ability to constrict in response to light. When addicted individuals stop using cocaine, they often become depressed. Smoking crack cocaine can produce a particularly aggressive paranoid behavior in users. High doses of cocaine and/or prolonged use can trigger paranoia. Cocaine's effects are short lived, and once the drug leaves the brain, the user experiences a "coke crash" that includes depression, irritability, and fatigue. However, the faster the absorption, the shorter the high lasts.The high from snorting may last 15 to 30 minutes, while that from smoking crack cocaine may last 5 to 10 minutes. The faster the absorption, the more intense the high. Duration of cocaine's immediate euphoric effects, which include energy, reduced fatigue, and mental clarity, depends on how it is used. Short-term effects of cocaine/crack include constricted peripheral blood vessels, dilated pupils, increased temperature, heart rate, blood pressure, insomnia, loss of appetite, feelings of restlessness, irritability, and anxiety.
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